http://localhost:80/xmlui/handle/123456789/1074 Wed, 13 May 2026 18:09:26 GMT 2026-05-13T18:09:26Z http://localhost:80/xmlui/handle/123456789/10956 Title: Design and synthesis of two new thiosemicarbazide based Schiff base metal complexes of nickel (II): DNA binding study and cytotoxicity profile analysis Authors: Chowdhury Niladri Biswas b, Manas , f , a Show more; Biswas, Niladri; Saha, Sandeepta; Biswas, Barun Kumar; Mandal, Deba Prasad; Bhattacharjee, Shamee; Rizzoli, Corrado; Roy Choudhury, Ruma; Roy Choudhury, Chirantan Abstract: Two new nickel (II) substituted thiosemicarbazone Schiff base complexes [Ni(meph)2] (1) [where H2meph = (2E)-N-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine-1-carbothioamide] and [Ni(hmm)2](NO3)2·2H2O (2) [where H2hmm = (2E)-2-[(2-hydroxyphenyl)methylidene]-N-methylhydrazine-1-carbothioamide] have been designed and synthesized by the condensation of 4-methyl-3-thiosemicarbazide with 2-acetylpyridine and salicylaldehyde respectively. Both the metal complexes 1 and 2 are characterized using different available spectroscopic techniques like FT-IR, UV–Vis spectroscopy, elemental analysis, and single crystal X-ray structure analysis. X-ray crystal structure analysis reveal that complex 1 and 2 are octahedral Ni(II) complexes. The calf-thymus CT-DNA-binding property of 1 and 2 has been evaluated by employing UV–Vis and fluorescence spectral titration. All the results show that CT-DNA binds with both nickel(II) complexes 1 and 2. In vitro cytotoxicity activity of complexes 1 and 2 toward A375 and MDA-MB-231 was evaluated using MTT assay and other methods which confirm that both complexes 1 and 2 behave as promising anti-cancer agents. Wed, 01 Jan 2025 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/10956 2025-01-01T00:00:00Z http://localhost:80/xmlui/handle/123456789/10955 Title: The Exceptional Tandem Catalyst Pt1Pd1 NPs Embedded on a Fe3O4-Polypyrrole Composite Serving in Both the Ethanol Oxidation Reaction and Oxygen Reduction Reaction in Direct Ethanol Fuel Cells Authors: Adhikary, Rajib; Datta, Jayati Abstract: The present study explores the contributory benefits of PtPd catalyst nanoparticles supported on a mixed valence iron oxide (Fe3O4) and polypyrrole (PPy) composite for validation in both the ethanol oxidation reaction and oxygen reduction reaction (ORR) in alkaline medium for low temperature direct ethanol fuel cells (DEFCs). The high electrochemical surface area (ECSA) for PtPd/PPy-Fe3O4 with smart intervention of Fe3O4 directly/indirectly in the EOR and ORR sequences makes this distinct catalyst a highly preferred choice in direct ethanol fuel cells with respect to reduced polarization loss, substantial current density output, and greater stability compared to the usual Pt or Pd single nanocatalysts supported over carbon, while the conducting polymer present in the composite matrix enhances the charge transfer ability within the direct ethanol fuel cell framework. The catalyst nanoparticles are found to be in the size range 4–5 nm, as revealed from structure and morphology studies. Ion chromatographic analysis quantifies the reaction intermediates, acetate and carbonate, to the extent of 366 and 251 ppm using 1 M ethanol solution, while a low yield of H2O2 is a testament to the major utility of the combinatorial approach in the ORR. The studies involved morphology determined through electron microscopy and electrochemical characterization with the help of potentiodynamic polarization and RDE-RRDE techniques. The catalytic preeminence of the nanostructured PtPd/PPy-Fe3O4 was manifested by the facile electrode kinetics at the anode and cathode, the low yield of H2O2 in the ORR, and the appreciable power density output of 47.65 mW/cm2 of the complete cell bearing enormous mass activity for both the EOR and ORR. This novel attempt of introducing the single robust catalyst at both ends ensures better catalyst utilization, imparts affordability, and avoids carbon corrosion in the fuel cell environment. Wed, 20 Nov 2024 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/10955 2024-11-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/10954 Title: Interaction with CT-DNA and in vitro cytotoxicity of two new copper(II)-based potential drugs derived from octanoic hydrazide ligands Authors: Chowdhury, Manas; Biswas, Niladri; Saha, Sandeepta; Rahaman, Ashikur; Sen Gupta, Poulami; Banerjee, Ankur; Mandal, Deba Prasad; Bhattacharjee, Shamee; Zangrando, Ennio; Sciortino, Giuseppe; Pisanu, Federico; Garribba, Eugenio; Roy Choudhury, Ruma; Roy Choudhury, Chirantan Abstract: Two copper(II) complexes [Cu(Hpmoh)(NO3)(NCS)] (1) and [Cu(peoh)(N3)]2 (2) were designed and synthesized by reaction of Cu(NO3)2·3H2O with hydrazone Schiff base ligands,abbreviated with Hpmoh and Hpeoh. Hpmoh and Hpeoh were prepared by condensation reaction of octanoic hydrazide with pyridine-2-carboxyaldehyde and 2-acetylpyridine, respectively. Complexes 1 and 2 were characterized using different analytical techniques such as FT-IR, UV–Vis, IR, EPR and single X-ray diffraction (XRD) analyses as well as computational methods (DFT). The XRD of 1 and 2 shows a mononuclear or a dinuclear structure with the copper(II) centre adopting a slightly distorted square pyramidal geometry. In water-containing solution and in DMSO, 1 and 2 undergo a partial transformation with formation of [Cu(Hpmoh)(NO3)(NCS)] (1) and [Cu(Hpmoh)(NO3)(H2O/DMSO)] (1a) in one system and [Cu(peoh)(N3)] (2a) in the other one, as supported by DFT calculations. Docking simulations confirmed that the intercalation is the preferred binding mode with DNA for 1, 1a and 2a, but suggested that the minor groove binding is also possible. A significant fluorescence quenching of the DNA–ethidium bromide conjugate was observed upon the addition of complexes 1 and 2 with a quenching constant around 104 M−1 s−1. Finally, both 1 and 2 were examined for anti-cancer activity using MDA-MB-231 (human breast adenocarcinoma) and A375 (malignant melanoma) cell lines through in vitro MTT assay which suggest comparable cancer cell killing efficacy, with the higher effectiveness of 2 due to the dissociation into two [Cu(peoh)(N3)] units. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/10954 2024-01-01T00:00:00Z http://localhost:80/xmlui/handle/123456789/8629 Title: Cytotoxic profile study, DNA and protein binding activity of a new dinuclear nickel(II) thiocyanato complex Authors: Roy Chowdhury, Ruma Abstract: One new binuclear Ni(II) complex with the molecular formula [Ni2(L)2(SCN)2(μ-SCN)2] (1) has been synthesized using a tridentate Schiff base ligand (L), formed by the condensation between quinoline-2-carboxaldehyde and N,N-dimethylethylenediamine. Complex 1 was characterized by FT-IR, UV-vis, and ESI-mass spectroscopy techniques, as well as elemental analysis, cyclic voltammetry, and single-crystal X-ray crystallography. The X-ray diffraction analysis of 1 indicated a centrosymmetric complex with nickel(II) centers in a distorted octahedral geometry and double bridged by thiocyanate anions via end-to-end (μ-1,3) fashion. The interaction of 1 with CT-DNA was explored by UV-vis and fluorescence spectroscopy, viscosity and cyclic voltammetry which indicated a moderate intercalation of the complex with CT-DNA. The protein binding study of 1 with BSA and HSA was investigated by various spectroscopic methods and indicated a static quenching process. In addition, 1 showed prominent in vitro cytotoxic activity against human melanoma (A375) and human breast carcinoma (MDA-MB-231) cell lines under the identical condition with IC50 value of 149.06 and 124.22 µM, respectively. Description: https://doi.org/10.1080/00958972.2022.2140408 Sun, 01 Jan 2023 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/8629 2023-01-01T00:00:00Z