http://localhost:80/xmlui/handle/123456789/9559 2026-04-05T17:20:39Z http://localhost:80/xmlui/handle/123456789/10655 Title: A Pilot Study on Presence of Parkinson’s Disease Risk Gene PARK7 in Population of West Bengal, India: A Preliminary Observation Authors: Chatterjee, Debasmita; Paira, Krishnendu; Singh, Banhishikha; Das, Satadal Abstract: ABSTRACT Introduction: The neurodegenerative Parkinson’s Disease (PD) is associated with different risk genes along with some environmental factors. Till date, there are few identified genes which play a pivotal role in the early onset of PD among the general population. Aim: To screen the presence of different risk genes of Parkinson’s disease along with associated environmental factors among randomly selected 62 urban participants. Materials and Methods: The present randomised control trial single blind pilot study was conducted in the Department of Biotechnology, Heritage Institute of Technology, Kolkata, West Bengal, India, from March 2021 to June 2021. The study participants were informed about the study and blood was collected from them. The genomic Deoxyribonucleic Acid(DNA) extraction was carried out following phenol chloroform extraction protocol and Polymerase Chain Reaction (PCR) was done with specific primers of the risk genes namely, Parkinson Disease 1 (PARK1) Alpha-synuclein (α-synuclein), Parkinson Disease 2 (PARK2) (Parkin), Parkinson Disease Protein 7 (PARK7) or DJ -1 and PINK 1. Protein Deglycase-1 (DJ-1) and PTEN Induced Kinase 1 (PINK1). The statistical analysis of the findings was done using Statistical package for the Social Sciences (SPSS) software version 21.0. Results: Out of 62 particpants, 47 were males and 15 were females and the age distribution of the participants was in between 21 years to >60 years. After obtaining specific band in agarose gel electrophoresis, 35 positive cases of PARK7 gene and one positive case of PARK2 gene were identified. Conclusion: There was a statistically significant association of different bacterial and viral infections with the PARK7 gene positive cases. PARK7 gene responsible for early onset of PD is significantly prevalent in the general population of West Bengal. 2023-01-01T00:00:00Z http://localhost:80/xmlui/handle/123456789/5939 Title: Low Sensitivity Third Order Lowpass Butterworth Filter Using CFA Authors: Nandy, R.; Kar, Mousiki; Das, Soumik Abstract: A third−order lowpass (LP) Butterworth filter design scheme using two CFA devices is presented. The analysis is carried out utilising the parasitic and transadmittance poles of the AD−844 type CFA elements. The circuit is practically active−insensitive with respect to the port mismatch errors (∈) of the devices. The filter characteristic had been satisfactorily verified with both PSPICE macromodel simulation and hardware circuit implementation for a frequency range 6MHz < fo< 30MHz. 2010-11-11T00:00:00Z http://localhost:80/xmlui/handle/123456789/5935 Title: Active-R Dual Input Integrator With Enhanced Time Constant Using a CDBA-Quadrature Oscillator Design Authors: Venkateswaran, P.; Das, Soumik; Nandi, Rabindra Abstract: A new dual-input integrator using a current differencing buffered amplifier (CDBA) element is presented ; the circuit needs a grounded capacitor and the time constant (τ ) has an enlargement factor being tunable by a single resistor. A sinusoid quadrature oscillator is realized thereafter with a double-integrator loop involving two such integrators. The designs are tested satisfactorily in a frequency-range of 1MHz-20MHz by both hardware implementation and PSPICE macromodel simulation. 2010-11-01T00:00:00Z http://localhost:80/xmlui/handle/123456789/5934 Title: Selective Filters and Sinusoidal Oscillators Using CFA Transimpedance Pole Authors: Nandy, R.; Bandyopadhyay, T.K.; Sanyal, S.K.; Das, Soumik Abstract: Using a single current feedback amplifier (CFA) device, two new variable frequency sinusoidal RC oscillators are presented. The transadmittance pole of the device (AD-844) has been utilized in the design for generating sine wave signals covering a range of 1 MHz ≤ f0 ≤ 31 MHz. Under open-loop conditions, both circuits exhibit resonance characteristics at moderate Q-values (1 ≤ Q ≤ 9). These responses have been experimentally verified with hardware circuit implementation and PSPICE macromodel simulation. Description: DOI: 10.1007/s00034-008-9089-9 2009-01-01T00:00:00Z